abstract：:Mutations in the OPTN gene are well known to be associated with the development of glaucoma. Recently, unique variations in the same gene have been reported in familial and sporadic Japanese cases of amyotrophic lateral sclerosis (ALS). We set out to evaluate the frequency of OPTN mutations in a sample of our familial...

journal_title：Neurobiology of aging

authors： Belzil VV,Daoud H,Desjarlais A,Bouchard JP,Dupré N,Camu W,Dion PA,Rouleau GA

更新日期：2011-03-01 00:00:00

abstract：:Nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) in the cholinergic basal forebrain (BF) during sleep deprivation (SD) is implicated in adenosine (AD) release and induction of recovery sleep. Aging is associated with impairments in sleep homeostasis, such as decrease in non-rapid eye movement sleep...

journal_title：Neurobiology of aging

authors： Rytkönen KM,Wigren HK,Kostin A,Porkka-Heiskanen T,Kalinchuk AV

更新日期：2010-11-01 00:00:00

abstract：:We recently reported evidence for an association between the individual variation in normal human episodic memory and a common variant of the KIBRA gene, KIBRA rs17070145 (T-allele). Since memory impairment is a cardinal clinical feature of Alzheimer's disease (AD), we investigated the possibility of an association be...

journal_title：Neurobiology of aging

authors： Corneveaux JJ,Liang WS,Reiman EM,Webster JA,Myers AJ,Zismann VL,Joshipura KD,Pearson JV,Hu-Lince D,Craig DW,Coon KD,Dunckley T,Bandy D,Lee W,Chen K,Beach TG,Mastroeni D,Grover A,Ravid R,Sando SB,Aasly JO,Heun R

更新日期：2010-06-01 00:00:00

abstract：:Neuronal alphabeta heteromeric and alpha7 homomeric nicotinic acetylcholine receptors (nAChRs) were compared in 4- and 27-month rabbits selected for learning proficiency. Sixty 4- and 60 27-month rabbits received the alpha7 nAChR agonist (MEM-3389), galantamine, or vehicle during training in trace eyeblink classical c...

journal_title：Neurobiology of aging

authors： Woodruff-Pak DS,Lehr MA,Li JG,Liu-Chen LY

更新日期：2010-06-01 00:00:00

abstract：:In this study we employed an ELISA assay to measure alpha-synuclein protein in lymphomonocytes from 78 PD patients and 78 controls. We correlated protein levels with demographic and clinical characteristics and with the chymotryptic and tryptic activities of the 20S proteasome. Alpha-synuclein levels were not signific...

journal_title：Neurobiology of aging

authors： Brighina L,Prigione A,Begni B,Galbussera A,Andreoni S,Piolti R,Ferrarese C

更新日期：2010-05-01 00:00:00

abstract：:Here we report the relationship between age at onset, clinical course and genotype in a family with combined LRRK2 G2019S and Parkin exon 2 deletions. In the combined mutation carriers the age at onset and clinical course was highly variable and not always younger than in the carriers of LRRK2 G2019S mutations alone. ...

journal_title：Neurobiology of aging

authors： Marras C,Klein C,Lang AE,Wakutani Y,Moreno D,Sato C,Yip E,Munhoz RP,Lohmann K,Djarmati A,Bi A,Rogaeva E

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Aging is a major risk factor for a variety of neurobiological diseases leading to variations of transcriptional expression in affected tissues. Reverse transcription of RNA followed by quantitative PCR is a powerful technique for detection and quantification of specific transcripts differentially expressed. ...

journal_title：Neurobiology of aging

authors： Sieber MW,Guenther M,Kohl M,Witte OW,Claus RA,Frahm C

更新日期：2010-04-01 00:00:00

abstract：:The integrity of white matter, as measured in vivo with diffusion tensor imaging (DTI), is disrupted in normal aging. A current consensus is that in adults advancing age affects anterior brain regions disproportionately more than posterior regions; however, the mainstay of studies supporting this anterior-posterior gr...

journal_title：Neurobiology of aging

authors： Sullivan EV,Rohlfing T,Pfefferbaum A

更新日期：2010-03-01 00:00:00

abstract：:Degeneration of septal neurons in Alzheimer's disease (AD) results in abnormal information processing at cortical circuits and consequent brain dysfunction. The septum modulates the activity of hippocampal and cortical circuits and is crucial to the initiation and occurrence of oscillatory activities such as the hippo...

journal_title：Neurobiology of aging

authors： Colom LV,Castañeda MT,Bañuelos C,Puras G,García-Hernández A,Hernandez S,Mounsey S,Benavidez J,Lehker C

更新日期：2010-01-01 00:00:00

abstract：:Brain-specific glutathione S-transferase Mu 3 (GSTM3) colocalizes with amyloid-beta plaques in Alzheimer's disease (AD). A functional polymorphism rs7483 in GSTM3 may contribute to the decrease in GSTM3 expression in AD. The association of the rs7483 SNP with late-onset AD and mild cognitive impairment (MCI) was evalu...

journal_title：Neurobiology of aging

authors： Maes OC,Schipper HM,Chong G,Chertkow HM,Wang E

更新日期：2010-01-01 00:00:00

abstract：:Association of the A2 allele of the human leukocyte antigen (HLA) with Alzheimer disease (AD) is still controversial. The authors evaluated HLA-A2 association with AD in 173 Italian AD patients, considering also the possible interaction with APOE pattern, age of onset and gender. No evidence of any association was fou...

journal_title：Neurobiology of aging

authors： Guerini FR,Calabrese E,Agliardi C,Zanzottera M,Franceschi M,Grimaldi LM,Nemni R,Ferrante P

更新日期：2009-12-01 00:00:00

abstract：:Dualistic effects of acetylcholine-esterase inhibitors on neuronal as well as vasoregulative function have been debated. This study investigated for the first time effects of medication on both components. Visually evoked potentials and resultant hemodynamic responses were assessed in Alzheimer patients (n=31) without...

journal_title：Neurobiology of aging

authors： Rosengarten B,Paulsen S,Burr O,Kaps M

更新日期：2009-12-01 00:00:00

abstract：:Since diabetes is a risk factor for Alzheimer's disease (AD), we asked if there is a functional interaction between high glucose and elevated beta amyloid peptide (Abeta) in cultured brain microvascular endothelial cells and presymptomatic AD transgenic mice. When cultured brain microvascular endothelial cells are exp...

journal_title：Neurobiology of aging

authors： Burdo JR,Chen Q,Calcutt NA,Schubert D

更新日期：2009-12-01 00:00:00

abstract：:Gangliosides have been shown to be necessary for beta-amyloid (Abeta) binding and aggregation. GD3 synthase (GD3S) is responsible for biosynthesis of the b- and c-series gangliosides, including two of the four major brain gangliosides. We examined Abeta-ganglioside interactions in neural tissue from mice lacking the g...

journal_title：Neurobiology of aging

authors： Bernardo A,Harrison FE,McCord M,Zhao J,Bruchey A,Davies SS,Jackson Roberts L 2nd,Mathews PM,Matsuoka Y,Ariga T,Yu RK,Thompson R,McDonald MP

更新日期：2009-11-01 00:00:00

abstract：:Hippocampal atrophy rates are useful in both diagnosing and tracking Alzheimer's disease (AD). However, cohorts and methods used to determine such rates are heterogeneous, leading to differences in reported annualised rates. We performed a meta-analysis of hippocampal atrophy rates in AD patients and matched controls ...

journal_title：Neurobiology of aging

authors： Barnes J,Bartlett JW,van de Pol LA,Loy CT,Scahill RI,Frost C,Thompson P,Fox NC

更新日期：2009-11-01 00:00:00

abstract：:The activity of beta-secretase (BACE1), the endo-protease essential for the production of amyloid beta (Abeta) peptides, is increased in brain of late-onset sporadic Alzheimer's disease (AD), and oxidative stress is the potential cause of this event. Oxidative stress up-regulates the expression and the activity of BAC...

journal_title：Neurobiology of aging

authors： Tamagno E,Guglielmotto M,Giliberto L,Vitali A,Borghi R,Autelli R,Danni O,Tabaton M

更新日期：2009-10-01 00:00:00

abstract：:Patients with Mild Cognitive Impairment (MCI), exhibiting both working memory and olfactory deficits are likely to progress to Alzheimer's disease (AD). Targeting this pre-clinical AD population with disease modifying agents or cognitive enhancers represents the best strategy for halting or delaying the impact of this...

journal_title：Neurobiology of aging

authors： Young JW,Sharkey J,Finlayson K

更新日期：2009-09-01 00:00:00

abstract：:Age-related brain changes are widely documented. Because of differences in measurement methods and case selection, the reported effects of age on regional grey and white matter brain volumes, however, are much more pronounced and widespread in neuroimaging than in postmortem studies. Consequently, the magnitude of the...

journal_title：Neurobiology of aging

authors： Piguet O,Double KL,Kril JJ,Harasty J,Macdonald V,McRitchie DA,Halliday GM

更新日期：2009-08-01 00:00:00

abstract：:Age-related declines in prefrontal functions and age-related declines in prefrontal serotonin (5-HT) are documented. The effect of 5-HT on prefrontal cortex (PFC) is also documented; however, no one has examined the effect of experimental 5-HT modulation on PFC in healthy older adults. We investigated the effect of 5-...

journal_title：Neurobiology of aging

authors： Lamar M,Cutter WJ,Rubia K,Brammer M,Daly EM,Craig MC,Cleare AJ,Murphy DG

更新日期：2009-07-01 00:00:00

abstract：:Abnormal interaction of beta-amyloid 42 (Abeta42) with copper, zinc and iron induce peptide aggregation and oxidation in Alzheimer's disease (AD). However, in health, Abeta degradation is mediated by extracellular metalloproteinases, neprilysin, insulin degrading enzyme (IDE) and matrix metalloproteinases. We investig...

journal_title：Neurobiology of aging

authors： Strozyk D,Launer LJ,Adlard PA,Cherny RA,Tsatsanis A,Volitakis I,Blennow K,Petrovitch H,White LR,Bush AI

更新日期：2009-07-01 00:00:00

abstract：:Accumulating evidence suggest that alterations in Reelin-mediated signaling may contribute to neuronal dysfunction associated with Alzheimer's disease (AD), the most common form of senile dementia. However, limited information is available on the effect of age, the major risk factor of AD, on Reelin expression. Here, ...

journal_title：Neurobiology of aging

authors： Knuesel I,Nyffeler M,Mormède C,Muhia M,Meyer U,Pietropaolo S,Yee BK,Pryce CR,LaFerla FM,Marighetto A,Feldon J

更新日期：2009-05-01 00:00:00

abstract：:While cerebrospinal fluid (CSF) biomarkers are of use in the prediction and diagnosis of Alzheimer's disease our understanding of the background effects of age and the ApoE genotype is limited. Seventy-eight community-based normal volunteers (mean age 60+/-10 years, range 36-86) were examined to determine the relation...

journal_title：Neurobiology of aging

authors： Glodzik-Sobanska L,Pirraglia E,Brys M,de Santi S,Mosconi L,Rich KE,Switalski R,Saint Louis L,Sadowski MJ,Martiniuk F,Mehta P,Pratico D,Zinkowski RP,Blennow K,de Leon MJ

更新日期：2009-05-01 00:00:00

abstract：:Parkinson's disease (PD) is a progressive neurodegenerative disease with typical motor symptoms due to the preferential loss of midbrain dopaminergic (mDA) neurons in the Substantia nigra pars compacta. Several proteins of the homeodomain family are crucial for the development of mDA neurons. These proteins remain exp...

journal_title：Neurobiology of aging

authors： Fuchs J,Mueller JC,Lichtner P,Schulte C,Munz M,Berg D,Wüllner U,Illig T,Sharma M,Gasser T

更新日期：2009-05-01 00:00:00

abstract：:Alzheimer's disease (AD) pathology has been described in Parkinson's disease (PD) patients with leucine-rich repeat kinase-2 (LRRK2) mutations. A common LRRK2 Gly2385Arg variant has been widely shown to be associated with a twofold increased risk of PD in various Asian populations. In a case control study, the frequen...

journal_title：Neurobiology of aging

authors： Tan EK,Lee J,Chen CP,Wong MC,Zhao Y

更新日期：2009-03-01 00:00:00

abstract：:Amyloid deposits are one of the hallmarks of Alzheimer's disease. Recent studies, in transgenic mice modeling Alzheimer's disease showed that, using in vivo, contrast agent-free, MRI, thalamic amyloid plaques are more easily detected than other plaques of the brain. Our study evaluated the characteristics of these tha...

journal_title：Neurobiology of aging

authors： Dhenain M,El Tannir El Tayara N,Wu TD,Guégan M,Volk A,Quintana C,Delatour B

更新日期：2009-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disease and is caused by an accumulation of A beta plaque deposits in the brains. Evidence is increasing that green tea flavonoids can protect cells from A beta-mediated neurotoxicity. However, the underlying mechanism remains unclear. Here, we used a human...

journal_title：Neurobiology of aging

authors： Lin CL,Chen TF,Chiu MJ,Way TD,Lin JK

更新日期：2009-01-01 00:00:00

abstract：:Regions of diffuse periventricular white matter hyperintensities (PVWMH) are a common finding on T(2)-weighted MRI scans of older subjects, but their aetiology remains unclear. The aim of this study was to characterize differences in water diffusion and magnetization transfer MRI parameters between macroscopically nor...

journal_title：Neurobiology of aging

authors： Bastin ME,Clayden JD,Pattie A,Gerrish IF,Wardlaw JM,Deary IJ

更新日期：2009-01-01 00:00:00

abstract：:Age-related structural brain changes have been demonstrated repeatedly but data on the effect of gender on age-related structural brain changes are conflicting. Using high-resolution T1-weighted magnetic resonance imaging and voxel-based morphometry, we examined a population of 133 healthy adults (women, 73; men, 60; ...

journal_title：Neurobiology of aging

authors： Nunnemann S,Wohlschläger AM,Ilg R,Gaser C,Etgen T,Conrad B,Zimmer C,Mühlau M

更新日期：2009-01-01 00:00:00

abstract：:The basal forebrain (BF) cholinergic system is selectively vulnerable in human brain diseases, while the cholinergic groups in the upper pons of the brainstem (BS) resist neurodegeneration. Cholinergic neurons (200 per region per animal) were laser-microdissected from five young (8 months) and five aged (24 months) F3...

journal_title：Neurobiology of aging

authors： Baskerville KA,Kent C,Personett D,Lai WR,Park PJ,Coleman P,McKinney M

更新日期：2008-12-01 00:00:00

abstract：:The loss of presynaptic markers is thought to represent a strong pathologic correlate of cognitive decline in Alzheimer's disease (AD). Spinophilin is a postsynaptic marker mainly located to the heads of dendritic spines. We assessed total numbers of spinophilin-immunoreactive puncta in the CA1 and CA3 fields of hippo...

journal_title：Neurobiology of aging

authors： Akram A,Christoffel D,Rocher AB,Bouras C,Kövari E,Perl DP,Morrison JH,Herrmann FR,Haroutunian V,Giannakopoulos P,Hof PR

更新日期：2008-09-01 00:00:00

abstract：:Distortions in the rest-activity rhythm in aging are commonly observed. Neurodegenerative changes of the suprachiasmatic nucleus have been proposed to underlie this disrupted rhythm. However, based on previous studies, it can be proposed that white matter hyperintensities (WMH) may also play a role in the altered rest...

journal_title：Neurobiology of aging

authors： Oosterman J,van Harten B,Vogels R,Gouw A,Weinstein H,Scheltens P,Scherder E

更新日期：2008-08-01 00:00:00

abstract：:The first hypothesis free genome wide association study on cognition recently revealed the thus far unknown association of a single nucleotide polymorphism (SNP) of the KIBRA gene with episodic memory in healthy young and middle aged volunteers. Here, we report the first independent replication of this finding in an i...

journal_title：Neurobiology of aging

authors： Schaper K,Kolsch H,Popp J,Wagner M,Jessen F

更新日期：2008-07-01 00:00:00

abstract：:In Parkinson disease, wild-type alpha-synuclein accumulates during aging, whereas alpha-synuclein mutations lead to an early onset and accelerated course of the disease. The generation of new neurons is decreased in regions of neurogenesis in adult mice overexpressing wild-type human alpha-synuclein. We examined the s...

journal_title：Neurobiology of aging

authors： Winner B,Rockenstein E,Lie DC,Aigner R,Mante M,Bogdahn U,Couillard-Despres S,Masliah E,Winkler J

更新日期：2008-06-01 00:00:00

abstract：:Amyloid plaques are a characteristic feature in Alzheimer's disease (AD). A novel non-toxic contrast agent is presented, Gd-DTPA-K6Abeta1-30, which is homologous to Abeta, and allows plaque detection in vivo. microMRI was performed on AD model mice and controls prior to and following intracarotid injection with Gd-DTP...

journal_title：Neurobiology of aging

authors： Sigurdsson EM,Wadghiri YZ,Mosconi L,Blind JA,Knudsen E,Asuni A,Scholtzova H,Tsui WH,Li Y,Sadowski M,Turnbull DH,de Leon MJ,Wisniewski T

更新日期：2008-06-01 00:00:00

abstract：:In an autopsy series of 19 individuals, age-ranged 24-94, a relatively age-spared region, the anterior-ventral thalamus, was analyzed by immunohistochemical techniques to visualize neurons (neurofilament protein), astrocytes (glial fibrillary acidic protein), microglial cells (CD68) and amyloid precursor protein. The ...

journal_title：Neurobiology of aging

authors： Guidolin D,Zunarelli E,Genedani S,Trentini GP,De Gaetani C,Fuxe K,Benegiamo C,Agnati LF

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:This longitudinal study used FDG-PET imaging to predict and monitor cognitive decline from normal aging. METHODS:Seventy-seven 50-80-year-old normal (NL) elderly received longitudinal clinical examinations over 6-14 years (561 person-years, mean per person 7.2 years). All subjects had a baseline FDG-PET scan...

journal_title：Neurobiology of aging

authors： Mosconi L,De Santi S,Li J,Tsui WH,Li Y,Boppana M,Laska E,Rusinek H,de Leon MJ

更新日期：2008-05-01 00:00:00

abstract：:Nicastrin and presenilin 1 are integral components of the high molecular weight gamma-secretase complexes that regulate proteolytic processing of various type I membrane proteins including amyloid precursor protein and Notch. At present, there is little information regarding the cellular distribution of nicastrin in t...

journal_title：Neurobiology of aging

authors： Kodam A,Vetrivel KS,Thinakaran G,Kar S

更新日期：2008-05-01 00:00:00

abstract：:Several polymorphisms in hepatic lipase (LIPC) are similar to apoE4 because they associate with cholesterol concentrations and, for rs6084, coronary artery disease (CAD). Since apoE4 is also a primary genetic risk factor for late-onset Alzheimer's disease (LOAD), LIPC single nucleotide polymorphisms (SNP)s represent e...

journal_title：Neurobiology of aging

authors： Zhu H,Taylor JW,Bennett DA,Younkin SG,Estus S

更新日期：2008-05-01 00:00:00

abstract：:The ability to maintain cognitive function during aging is a complex process subject to genetic and environmental influences. Alzheimer's disease (AD) is the most common disorder causing cognitive decline among the elderly. Among those with AD, there is broad variation in the relationship between AD neuropathology and...

journal_title：Neurobiology of aging

authors： Wilmot B,McWeeney SK,Nixon RR,Montine TJ,Laut J,Harrington CA,Kaye JA,Kramer PL

更新日期：2008-04-01 00:00:00

abstract：:Time-dependent changes in brain activity were assessed in a group of older adults who maintained good physical and cognitive health at years 1, 3, 5, 7, and 9 of the Baltimore Longitudinal Study of Aging neuroimaging study. Each year, these participants underwent PET scans during rest and delayed verbal and figural re...

journal_title：Neurobiology of aging

authors： Beason-Held LL,Kraut MA,Resnick SM

更新日期：2008-04-01 00:00:00